Kimio Akagawa Selected Research

Syntaxin 1

1/2021	Syntaxin 1A Gene Is Negatively Regulated in a Cell/Tissue Specific Manner by YY1 Transcription Factor, Which Binds to the -183 to -137 Promoter Region Together with Gene Silencing Factors Including Histone Deacetylase.
1/2021	Syntaxin 1B regulates synaptic GABA release and extracellular GABA concentration, and is associated with temperature-dependent seizures.
5/2004	Activation of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, by phorbol 12-myristate 13-acetate (PMA) suppresses glucose transport into astroglioma cells via the glucose transporter-1 (GLUT-1).
2/2003	Expression of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, is enhanced by phorbol-ester stimulation in astroglioma: participation of the PKC signaling pathway.

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Kimio Akagawa Research Topics

Disease

3	Cognitive Dysfunction 01/2014 - 12/2011
3	Alzheimer Disease (Alzheimer's Disease) 11/2013 - 08/2004
2	Necrosis 07/2006 - 12/2003
2	Astrocytoma (Pilocytic Astrocytoma) 05/2004 - 02/2003
1	Neurodevelopmental Disorders 01/2021
1	Epileptic Syndromes 01/2021
1	Hyperthermia 01/2021
1	Febrile Seizures (Febrile Seizure) 01/2021
1	Fever (Fevers) 01/2021
1	Seizures (Absence Seizure) 01/2021
1	Neuralgia (Stump Neuralgia) 01/2014
1	Hypoxia (Hypoxemia) 01/2014
1	Dementia (Dementias) 11/2013
1	Wolfram Syndrome (Syndrome, Wolfram) 11/2013
1	Vesicular Stomatitis 08/2005
1	Ischemia 08/2003
1	Williams Syndrome (Williams-Beuren Syndrome) 02/2003

Drug/Important Bio-Agent (IBA)

4	Syntaxin 1IBA 01/2021 - 02/2003
3	Proteins (Proteins, Gene)FDA Link 12/2011 - 05/2004
3	Glucose (Dextrose)FDA LinkGeneric 07/2006 - 08/2003
3	Matrix Metalloproteinases (MMPs)IBA 07/2006 - 08/2003
2	Neuroprotective AgentsIBA 01/2014 - 07/2006
2	Oxygen (Dioxygen)IBA 07/2006 - 08/2003
1	Pharmaceutical PreparationsIBA 01/2021
1	gamma-Aminobutyric Acid (GABA)IBA 01/2021
1	Analgesics (Analgesic Drugs)IBA 01/2014
1	Pregabalin (Lyrica)FDA Link 01/2014
1	Nitric Oxide DonorsIBA 01/2014
1	Indicators and Reagents (Reagents)IBA 01/2014
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2014
1	EnzymesIBA 01/2014
1	Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric 01/2014
1	cobaltous chloride (cobalt(II)chloride)IBA 01/2014
1	oligonolIBA 11/2013
1	PolyphenolsIBA 11/2013
1	Messenger RNA (mRNA)IBA 11/2013
1	DNA (Deoxyribonucleic Acid)IBA 11/2013
1	Transcription Factors (Transcription Factor)IBA 12/2011
1	Propofol (Diprivan)FDA LinkGeneric 07/2006
1	Flavin-Adenine Dinucleotide (FAD)IBA 07/2005
1	PresenilinsIBA 08/2004
1	phorbolIBA 05/2004
1	Adenosine Triphosphate (ATP)IBA 08/2003
1	NitrogenIBA 08/2003
1	Phorbol EstersIBA 02/2003
1	Neurotransmitter Agents (Neurotransmitter)IBA 02/2003